Difference between revisions of "Part:BBa K4165216"
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Fusion protein consists of Tau binding peptide (TD28) for tau targeting and Coh2 protein [BBa_K4165003] that bind to Docs [BBa_K3396000] to form the protac system. | Fusion protein consists of Tau binding peptide (TD28) for tau targeting and Coh2 protein [BBa_K4165003] that bind to Docs [BBa_K3396000] to form the protac system. | ||
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===Usage and Biology=== | ===Usage and Biology=== | ||
| + | Protac system is known to be a promising one for targeting and signaling many diseases and biological application so according to our project aim, we introduced this fusion protein with different linker length and tau binding peptide to be a target for degradation of Tau aggregation in our updated protac version system "Snitch system". Furthermore, that can be validated by wet-lab results by in vitro or in vivo testing. | ||
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Revision as of 13:53, 7 October 2022
Coh2 linked with tau binding peptide (TD28) & (GSGS) linker
Fusion protein consists of Tau binding peptide (TD28) for tau targeting and Coh2 protein [BBa_K4165003] that bind to Docs [BBa_K3396000] to form the protac system.
Usage and Biology
Protac system is known to be a promising one for targeting and signaling many diseases and biological application so according to our project aim, we introduced this fusion protein with different linker length and tau binding peptide to be a target for degradation of Tau aggregation in our updated protac version system "Snitch system". Furthermore, that can be validated by wet-lab results by in vitro or in vivo testing.
Sequence and Features
Assembly Compatibility:
- 10INCOMPATIBLE WITH RFC[10]Illegal PstI site found at 436
- 12INCOMPATIBLE WITH RFC[12]Illegal PstI site found at 436
- 21COMPATIBLE WITH RFC[21]
- 23INCOMPATIBLE WITH RFC[23]Illegal PstI site found at 436
- 25INCOMPATIBLE WITH RFC[25]Illegal PstI site found at 436
- 1000COMPATIBLE WITH RFC[1000]