Difference between revisions of "Part:BBa K4143336"

Revision as of 23:49, 6 October 2022

Antimicrobial Pepide: HBCM2

Antimicrobial peptides, or AMPs, are naturally occurring peptides used by organisms to combat pathogenic infections.They have recently gained traction as an alternative to antibiotics due to the rise of antimicrobial-resistant infections. HBCM2, an α-helical AMP hybrid of cecropin and melittin peptides, is particularly active against gram-negative bacteria. Its target is membrane permeabilization and has a Minimum Inhibitory Concentration of 5 μM (E. coli C43(DE3))

Usage and Biology

References

[1]T. W. Giessen and P. A. Silver, “Widespread distribution of encapsulin nanocompartments reveals functional diversity,” Nature Microbiology, vol. 2, no. 6, p. 17029, Mar. 2017, doi: 10.1038/nmicrobiol.2017.29.

[2]J. A. Jones, A. S. Cristie-David, M. P. Andreas, and T. W. Giessen, “Triggered reversible disassembly of an engineered protein nanocage,” bioRxiv, p. 2021.04.19.440480, Jan. 2021, doi: 10.1101/2021.04.19.440480.

Sequence and Features