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Revision as of 12:38, 9 October 2022


HTRA Binding Peptide 11

part encodes for a synthetic peptide that binds to the PDZ domain of HTRA1 protein

Usage and Biology

Synthetic peptide acquired by Phage display, Binds specifically to PDZ domain of HTRA1 and HTRA3 Proteins with G of –7.1 and IC50 of 23 ± 3

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

Functional Parameters

Got score of 5 out of 6 in our Quality assessment code after modeling by AlphaFold2.0

cbeta_deviations = 0, clashscore = 25, molprobity = 3.86, ramachandran_favored = 66.67, ramachandran_outliers = 16.67, Qmean_4 = -6.45183, Qmean6 = -5.513969

Modeling


                 Figure 1.: 3D Model of H1K peptide Modelled by AlphaFold2.0 displayed in Pyomol