Difference between revisions of "Part:BBa K4165139"
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<p style=" font-weight: bold; font-size:14px;"> Modeling </p>
 
<p style=" font-weight: bold; font-size:14px;"> Modeling </p>
  
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TLKIVW were modeled by alphafold2 and apptest.
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TLKIVW were modeled by AlphaFold2 and Apptest. The best model obtained from Apptest
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best model obtained from apptest
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<p><img src="https://static.igem.wiki/teams/4165/wiki/parts-registry/tlkivw-pars.png" style="margin-left:400px;" alt="" width="500" /></p>
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<p><img src="https://static.igem.wiki/teams/4165/wiki/parts-registry/tlkivw-pars.png" style="margin-left:100px;" alt="" width="800" /></p>
 
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HAmZA
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===References===
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1.Sievers, S. A., Karanicolas, J., Chang, H. W., Zhao, A., Jiang, L., Zirafi, O., ... & Eisenberg, D. (2011). Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature, 475(7354), 96-100.
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===Functional Parameters===
 
===Functional Parameters===
 
<partinfo>BBa_K4165139 parameters</partinfo>
 
<partinfo>BBa_K4165139 parameters</partinfo>
 
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Revision as of 16:46, 5 October 2022


TLKIVW Peptide

Tau binding peptide targeting the PHF seed of Tau

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Dry Lab

Modeling

TLKIVW were modeled by AlphaFold2 and Apptest. The best model obtained from Apptest 


                            Figure 1.: Predicted 3D structure of Synthetic peptide TLKIVW.

modeled by alphafold2 and apptest. best model obtained from apptest


Table 1.: Quality assessment parameters of TLKIVW model.


References

1.Sievers, S. A., Karanicolas, J., Chang, H. W., Zhao, A., Jiang, L., Zirafi, O., ... & Eisenberg, D. (2011). Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature, 475(7354), 96-100.