Difference between revisions of "Part:BBa K4117888"
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− | + | UGT1A3 in this pathway plays a significant role in metabolic section, working upon the sensing section. Tetrahydrocannabinol (Δ9 -THC), the primary psychoactive ingredient in marijuana, is subject to cytochrome P450 oxidation and subsequent UDP-glucuronosyltransferase(UGT)-dependent glucuronidation. In our system, Δ-9-ThC is hydroxylated by CYP2C9 (BBa_K4117002) and CYP2C19 (BBa_K4117022), remaining psychoactive. The major product of CYP2C9 and CYP2C19 metabolism, 11-OH-Δ-9-ThC, was further oxidized to THC-COOH. Then UGT1A3, which catalyzes the glucuronidation of the former substrate, increases the metabolite's water solubility, thereby facilitating excretion into the urine. | |
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Revision as of 18:27, 11 October 2022
UGT1A3
UGT1A3 in this pathway plays a significant role in metabolic section, working upon the sensing section. Tetrahydrocannabinol (Δ9 -THC), the primary psychoactive ingredient in marijuana, is subject to cytochrome P450 oxidation and subsequent UDP-glucuronosyltransferase(UGT)-dependent glucuronidation. In our system, Δ-9-ThC is hydroxylated by CYP2C9 (BBa_K4117002) and CYP2C19 (BBa_K4117022), remaining psychoactive. The major product of CYP2C9 and CYP2C19 metabolism, 11-OH-Δ-9-ThC, was further oxidized to THC-COOH. Then UGT1A3, which catalyzes the glucuronidation of the former substrate, increases the metabolite's water solubility, thereby facilitating excretion into the urine.
Sequence and Features
Assembly Compatibility:
- 10INCOMPATIBLE WITH RFC[10]Illegal EcoRI site found at 4599
Illegal XbaI site found at 693
Illegal SpeI site found at 713
Illegal PstI site found at 1214 - 12INCOMPATIBLE WITH RFC[12]Illegal EcoRI site found at 4599
Illegal SpeI site found at 713
Illegal PstI site found at 1214 - 21INCOMPATIBLE WITH RFC[21]Illegal EcoRI site found at 4599
Illegal BglII site found at 4257
Illegal BamHI site found at 2887
Illegal BamHI site found at 3444 - 23INCOMPATIBLE WITH RFC[23]Illegal EcoRI site found at 4599
Illegal XbaI site found at 693
Illegal SpeI site found at 713
Illegal PstI site found at 1214 - 25INCOMPATIBLE WITH RFC[25]Illegal EcoRI site found at 4599
Illegal XbaI site found at 693
Illegal SpeI site found at 713
Illegal PstI site found at 1214
Illegal AgeI site found at 3031 - 1000INCOMPATIBLE WITH RFC[1000]Illegal SapI.rc site found at 732