Difference between revisions of "Part:BBa K237002"
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__NOTOC__ | __NOTOC__ | ||
<partinfo>BBa_K237002 short</partinfo> | <partinfo>BBa_K237002 short</partinfo> | ||
− | RIP or RNAIII inhibiting peptide is a heptapeptide capable of severely reducing the Qourum sensing(QS) abilities of Staphylococcus species. RIP effectively works as an antibiotic in its inhibition of bacterial | + | RIP or RNAIII inhibiting peptide is a heptapeptide capable of severely reducing the Qourum sensing(QS) abilities of Staphylococcus species [1]. RIP effectively works as an antibiotic in its inhibition of bacterial biofilm-formation. It is important to note that even though it has the effect of an antibiotic [1] on bacterial load, the mechanism is a novel one, and doesn't appear to induce bacterial resistance [1]. |
− | RIP has the sequence YSPXTNF and has been tested extensively in a synthetic (as in | + | RIP has the sequence YSPXTNF and has been tested extensively in a synthetic (as in chemical synthesis) form for ability to inhibit bacterial infections in mice [1] and biofilm formation on human cells [2]. |
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<!-- Add more about the biology of this part here | <!-- Add more about the biology of this part here | ||
===Usage and Biology=== | ===Usage and Biology=== | ||
+ | This generator is under constitutive expression by a TetR repressible promoter <partinfo>BBa_R0040</partinfo>. | ||
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+ | ===References=== | ||
+ | [1] Suppression of Drug-Resistant Staphylococcal Infections by the Quorum-Sensing Inhibitor RNAIII-Inhibiting Peptide. Journal of Infectious Diseases [serial on the Internet]. (2004, July 15), [cited October 21, 2009]; 190(2): 318-320. Available from: Academic Search Premier. | ||
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+ | Prevention of Staphylococcus aureus biofilm on dialysis catheters and adherence to human cells. Balaban N, Gov Y, Bitler A, Boelaert JR. Kidney Int 2003; 63:340–5. | ||
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Revision as of 07:27, 21 October 2009
Constitutive RIP Generator. RIP - Quorum sensing inhibitor of Staphylococcus spp.
RIP or RNAIII inhibiting peptide is a heptapeptide capable of severely reducing the Qourum sensing(QS) abilities of Staphylococcus species [1]. RIP effectively works as an antibiotic in its inhibition of bacterial biofilm-formation. It is important to note that even though it has the effect of an antibiotic [1] on bacterial load, the mechanism is a novel one, and doesn't appear to induce bacterial resistance [1].
RIP has the sequence YSPXTNF and has been tested extensively in a synthetic (as in chemical synthesis) form for ability to inhibit bacterial infections in mice [1] and biofilm formation on human cells [2].
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]