Difference between revisions of "Part:BBa K4175006"

 
 
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4-1BB is a costimulatory receptor on activated T cells. The ligation of 4-1BB will trigger a signal cascade, which leads to activation of anti-apoptotic molecules, increased cytokine secretion, and enhanced cytotoxicity (Chester et al., 2018). It has been widely used in the second-generation CAR and is found to improve the persistence of CAR-T cells by enhancing CAR-T survival and expansion through non-canonical NFκB signaling pathway (Philipson et al., 2020). In our project, 4-1BB is used in anti-CD19 CAR (<partinfo>BBa_K4175012</partinfo>).
  
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===Sequence and Features===
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===Usage and Biology===
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<span class='h3bb'>Sequence and Features</span>
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<partinfo>BBa_K4175006 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_K4175006 SequenceAndFeatures</partinfo>
  
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===References===
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Chester, C., Sanmamed, M.F., Wang, J., Melero, I., 2018. Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies. Blood 131, 49–57. https://doi.org/10.1182/blood-2017-06-741041
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Philipson, B.I., O’Connor, R.S., May, M.J., June, C.H., Albelda, S.M., Milone, M.C., 2020. 4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling. Sci. Signal. 13, eaay8248. https://doi.org/10.1126/scisignal.aay8248
  
 
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Latest revision as of 11:19, 10 October 2022


4-1BB

4-1BB is a costimulatory receptor on activated T cells. The ligation of 4-1BB will trigger a signal cascade, which leads to activation of anti-apoptotic molecules, increased cytokine secretion, and enhanced cytotoxicity (Chester et al., 2018). It has been widely used in the second-generation CAR and is found to improve the persistence of CAR-T cells by enhancing CAR-T survival and expansion through non-canonical NFκB signaling pathway (Philipson et al., 2020). In our project, 4-1BB is used in anti-CD19 CAR (BBa_K4175012).

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

References

Chester, C., Sanmamed, M.F., Wang, J., Melero, I., 2018. Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies. Blood 131, 49–57. https://doi.org/10.1182/blood-2017-06-741041

Philipson, B.I., O’Connor, R.S., May, M.J., June, C.H., Albelda, S.M., Milone, M.C., 2020. 4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling. Sci. Signal. 13, eaay8248. https://doi.org/10.1126/scisignal.aay8248