Difference between revisions of "Part:BBa K3861010"
 
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Pep8 is an artificial peptide that was shown to play a potential role in the re-induction of p53 translation which leads to decreased tumor growth in mice xenograft (Luccesi et al., 2019). p53 acts as tumor suppressor by preserving the integrity of the genome. p53 loss of function is associated with more than half of all human cancers (Vogelstein et al., 2000; Vousden and Prives, 2009). Further, Pep8 was shown to sensitize cancer cells to an anticancer drug doxorubicin (Luccesi et al, 2019). Pep8 is part of the composite parts <a href="https://parts.igem.org/Part:BBa_K3861024">BBa_K3861024</a> and <a href="https://parts.igem.org/Part:BBa_K3861026">BBa_K3861026</a>.
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Pep8 is an artificial peptide that was shown to play a potential role in the re-induction of p53 translation which leads to decreased tumor growth in mice xenograft.<sup>1</sup> p53 acts as tumor suppressor by preserving the integrity of the genome. p53 loss of function is associated with more than half of all human cancers.<sup>2,3</sup> Further, Pep8 was shown to sensitize cancer cells to an anticancer drug doxorubicin.<sup>1</sup> Pep8 is part of the composite parts <a href="https://parts.igem.org/Part:BBa_K3861024">BBa_K3861024</a> and <a href="https://parts.igem.org/Part:BBa_K3861026">BBa_K3861026</a>.
 
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<partinfo>BBa_K3861010 parameters</partinfo>
 
<partinfo>BBa_K3861010 parameters</partinfo>
 
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==='''References'''===
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1. Lucchesi, C. A., Zhang, J., Ma, B., Chen, M. & Chen, X. Disruption of the Rbm38-eIF4E Complex with a Synthetic Peptide Pep8 Increases p53 Expression. Cancer Res. 79, 807–818 (2019).
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2. Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307–310 (2000).
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3. Vousden, K. H. & Prives, C. Blinded by the Light: The Growing Complexity of p53. Cell 137, 413–431 (2009).

Latest revision as of 17:51, 19 October 2021


Pep8

Pep8 is an artificial peptide that was shown to play a potential role in the re-induction of p53 translation which leads to decreased tumor growth in mice xenograft.1 p53 acts as tumor suppressor by preserving the integrity of the genome. p53 loss of function is associated with more than half of all human cancers.2,3 Further, Pep8 was shown to sensitize cancer cells to an anticancer drug doxorubicin.1 Pep8 is part of the composite parts BBa_K3861024 and BBa_K3861026.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


References

1. Lucchesi, C. A., Zhang, J., Ma, B., Chen, M. & Chen, X. Disruption of the Rbm38-eIF4E Complex with a Synthetic Peptide Pep8 Increases p53 Expression. Cancer Res. 79, 807–818 (2019).
2. Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307–310 (2000).
3. Vousden, K. H. & Prives, C. Blinded by the Light: The Growing Complexity of p53. Cell 137, 413–431 (2009).