Difference between revisions of "Part:BBa K4040034"
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In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It is implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC and is also involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. | In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It is implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC and is also involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. | ||
| + | [[File:T--NMU_China--her2.png|thumb|none|300px|<b>Figure 1.</b> The structure of HER2.]] | ||
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Revision as of 05:44, 7 October 2021
Truncated HER2
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BglII site found at 1040
Illegal BamHI site found at 1235 - 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal NgoMIV site found at 595
Illegal NgoMIV site found at 658
Illegal NgoMIV site found at 1027 - 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI.rc site found at 52
Illegal BsaI.rc site found at 1135
Usage and Biology
HER2 is a protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. It is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. HER2 Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It is implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC and is also involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
