Difference between revisions of "Part:BBa K3861010"
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| + | Pep8 is an artificial peptide that was shown to play a potential role in the re-induction of p53 translation which leads to decreased tumor growth in mice xenograft (Luccesi et al., 2019). p53 acts as tumor suppressor by preserving the integrity of the genome. p53 loss of function is associated with more than half of all human cancers (Vogelstein et al., 2000; Vousden and Prives, 2009). Further, Pep8 was shown to sensitize cancer cells to an anticancer drug doxorubicin (Luccesi et al, 2019). Pep8 is part of the composite parts <a href="https://parts.igem.org/Part:BBa_K3861024">BBa_K3861024</a> and <a href="https://parts.igem.org/Part:BBa_K3861026">BBa_K3861026</a>. | ||
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<!-- Add more about the biology of this part here | <!-- Add more about the biology of this part here | ||
Revision as of 16:06, 17 October 2021
Pep8
Pep8 is an artificial peptide that was shown to play a potential role in the re-induction of p53 translation which leads to decreased tumor growth in mice xenograft (Luccesi et al., 2019). p53 acts as tumor suppressor by preserving the integrity of the genome. p53 loss of function is associated with more than half of all human cancers (Vogelstein et al., 2000; Vousden and Prives, 2009). Further, Pep8 was shown to sensitize cancer cells to an anticancer drug doxorubicin (Luccesi et al, 2019). Pep8 is part of the composite parts BBa_K3861024 and BBa_K3861026.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]