Difference between revisions of "Part:BBa K4040013"

Revision as of 13:19, 29 September 2021

mIL-6R

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (GP130BBa_K4040032), a receptor subunit also shared by many other cytokines. The classical signaling pathway is triggered by the hemerer complex formed by mIL-6R. The usage in our project can be found in IL6R-TCS-Gal4-KRAB(BBa_K4040021) and IL6R-TCS-tTA(BBa_K4040022).

References

Narazaki M, Kishimoto T. The Two-Faced Cytokine IL-6 in Host Defense and Diseases. Int J Mol Sci. 2018 Nov 9;19(11):3528. doi: 10.3390/ijms19113528. PMID: 30423923; PMCID: PMC6274717.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
INCOMPATIBLE WITH RFC[25]
Illegal NgoMIV site found at 142
Illegal NgoMIV site found at 166
Illegal NgoMIV site found at 238
Illegal NgoMIV site found at 250
1000
COMPATIBLE WITH RFC[1000]

@@ Line 3: / Line 3: @@
 <partinfo>BBa_K4040013 short</partinfo>
-This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (GP130), a receptor subunit also shared by many other cytokines. The classical signaling pathway is triggered by the hemerer complex formed by mIL-6R.
+This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (<b>GP130</b><partinfo>BBa_K4040032</partinfo>), a receptor subunit also shared by many other cytokines. The classical signaling pathway is triggered by the hemerer complex formed by mIL-6R.
-The usage in our project can be found in
+The usage in our project can be found in <b>IL6R-TCS-Gal4-KRAB</b>(<partinfo>BBa_K4040021</partinfo>) and <b> IL6R-TCS-tTA</b>(<partinfo>BBa_K4040022</partinfo>).
 ===References===