Difference between revisions of "Part:BBa K4040000"

Revision as of 10:27, 7 September 2021

Intracellular Domain of the MEGF10 Protein MEGF10 belongs to the MEGF family.It is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility, and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain.

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 <partinfo>BBa_K4040000 short</partinfo>
-<h3><b>Background and structure of CAR-MEGF10</b></h3>
+MEGF10 belongs to the MEGF family.It is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility, and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain.
-The function of CAR-MEGF10 is the same as the CAR&#947;, which increases the phagocytosis of the macrophages. And the structure is also highly similar to the CAR&#947;, with the only difference lying in the intracellular domain of the CAR, in which the common &#947; subunit of Fc receptors is replaced by MEGF10.
-<h3><b>The mechanism of CAR-MEGF10</b></h3>
-After the extracellular αS-scFv domain binds to the S protein of SARS-CoV-2, the intracellular cytosolic Immunoreceptor Tyrosine-based Activation Motifs (ITAMs) are activated with the help of the Src family kinases. And the SH2 binding domains for the protein expressing SH2 matching domains will be further exposed due to the space conformation change. The protein expressing SH2 matching domains, protein Syk, a phagocytic signaling effector can then active the downstream signaling transduction cascades and initiate the phagocytosis in our CARγ-macrophages eventually.