Difference between revisions of "Part:BBa I712020"

Revision as of 20:15, 28 July 2021

Homo sapiens caspase 3

Homo sapiens caspase 3, apoptosis-related cysteine peptidase (transcript variant beta).

Information contributed by City of London UK (2021)

Part information is collated here to help future users of the BioBrick registry.

Metadata:

Group: City of London UK 2021

Author: Julian Chen

Summary: Added information collated from existing scientific studies

Part is involved in the activation cascade of caspases contributing to apoptosis.

At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond

Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9

The part is also involved in the cleavage of Huntingtin (HTT gene).

Activity Regulation

Part is inhibited via isatin sulfonamides

Sequence and Features