Difference between revisions of "Part:BBa K3582004"
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===References=== | ===References=== | ||
− | *[1] Baratin, M., Roetynck, S., Pouvelle, B., Lemmers, C., Viebig, N. K., Johansson, S., . . . Ugolini, S. (2007 | + | *[1]Baratin, M., Roetynck, S., Pouvelle, B., Lemmers, C., Viebig, N. K., Johansson, S., Bierling, P., Scherf, A., Gysin, J., Vivier, E., & Ugolini, S. (2007). Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells. PloS one, 2(2), e228. https://doi.org/10.1371/journal.pone.0000228 |
*[2]Hviid L, Jensen AT. PfEMP1 ‐ A parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis. Adv Parasitol. 2015;88:51‐84 | *[2]Hviid L, Jensen AT. PfEMP1 ‐ A parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis. Adv Parasitol. 2015;88:51‐84 | ||
*[3]Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TA. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell. 1988;52:925–933. | *[3]Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TA. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell. 1988;52:925–933. |
Latest revision as of 07:24, 26 October 2020
The DBLb domain of PF11_0521 PfEMP1
This biobrick is thought to be able to produce the DBLb domain of PfEMP-1. Plasmodium falciparum erythrocyte membrane protein 1 EMP1 is encoded by the clonally variant var gene family with approximately 60 members per parasite genome. The adhesion process of the PfEMP1 proteins is often described as a way for the parasite to evade splenic clearance and has also been reported as associated with vascular obstruction of vital organs leading to major pathological events.[1]. These proteins are also known for their ability to mediate adhesion of IEs to host receptors in the vasculature.[2]
The binding of PfEMP1 to ICAM-1 is mediated by a subset of Duffy binding-like (DBL) domains, the DBLβ domains, which are found in either A-type or BC-type PfEMP1.[4][5][6][7]. The PfEMP1 protein to the D1 domain of ICAM-1[3].
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BamHI site found at 1407
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 1113
- 1000COMPATIBLE WITH RFC[1000]
References
- [1]Baratin, M., Roetynck, S., Pouvelle, B., Lemmers, C., Viebig, N. K., Johansson, S., Bierling, P., Scherf, A., Gysin, J., Vivier, E., & Ugolini, S. (2007). Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells. PloS one, 2(2), e228. https://doi.org/10.1371/journal.pone.0000228
- [2]Hviid L, Jensen AT. PfEMP1 ‐ A parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis. Adv Parasitol. 2015;88:51‐84
- [3]Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TA. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell. 1988;52:925–933.
- [4]A. Bengtsson et a., A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies. J. Immunol. 190, 240–249 (2013).
- [5]E. Carrington et al., In silico guided reconstruction and analysis of ICAM-1-binding var genes from Plasmodium falciparum. Sci. Rep. 8, 3282 (2018)
- [6] D. P. G. Howell et al., Mapping a common interaction site used by Plasmodium falciparum Duffy binding-like domains to bind diverse host receptors. Mol. Microbiol. 67, 78–87 (2008).CrossRefPubMedGoogle Scholar
- [7] H. Janes et al., Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family. PLoS Pathog. 7, e1002032 (2011).