Difference between revisions of "Part:BBa K223053"
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Latest revision as of 17:35, 23 October 2020
hIL-6 Generator (Freiburg-compatible)
This gene generates Interleukin 6, an important cell signaling molecule that acts as both a pro- and anti-inflammatory cytokine
Sequence and Features
- 10INCOMPATIBLE WITH RFC[10]Illegal prefix found in sequence at 1
Illegal suffix found in sequence at 600 - 12INCOMPATIBLE WITH RFC[12]Illegal EcoRI site found at 1
Illegal NheI site found at 465
Illegal SpeI site found at 601
Illegal PstI site found at 615
Illegal NotI site found at 7
Illegal NotI site found at 608 - 21INCOMPATIBLE WITH RFC[21]Illegal EcoRI site found at 1
- 23INCOMPATIBLE WITH RFC[23]Illegal prefix found in sequence at 1
Illegal suffix found in sequence at 601 - 25INCOMPATIBLE WITH RFC[25]Illegal prefix found in sequence at 1
Illegal suffix found in sequence at 591 - 1000INCOMPATIBLE WITH RFC[1000]Illegal BsaI.rc site found at 156
Illegal SapI site found at 570
MIT_MAHE 2020
Summary
This gene generates Interleukin 6, an important cell signaling molecule that acts as both a pro- and anti-inflammatory cytokine. This cytokine has a wide variety of biological functions in immunity, tissue regeneration, and metabolism. IL6 binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells.
References
1. Kang, S., Tanaka, T., Narazaki, M., & Kishimoto, T. (2019). Targeting Interleukin-6 Signaling in Clinic. Immunity, 50(4), 1007–1023. https://doi.org/10.1016/j.immuni.2019.03.026
2. Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004). IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. The Journal of clinical investigation, 113(9), 1271–1276. https://doi.org/10.1172/JCI20945 "