Difference between revisions of "Part:BBa K3351004"
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| − | + | ===Summary=== | |
A human antimicrobial peptide with 32 amino acids.HD5 fights against Gram-negative bacteria by disrupting and damaging the membrane and penetrating into the cytoplasm. Different oligomeric states were found to perform different degrees of antimicrobial activity. In solution, dimeric and tetrameric states are generally observed. A dimer was found to be the most active form, whereas a tetramer is the largest stable found in solution. | A human antimicrobial peptide with 32 amino acids.HD5 fights against Gram-negative bacteria by disrupting and damaging the membrane and penetrating into the cytoplasm. Different oligomeric states were found to perform different degrees of antimicrobial activity. In solution, dimeric and tetrameric states are generally observed. A dimer was found to be the most active form, whereas a tetramer is the largest stable found in solution. | ||
Moreover, HD5 also shows anti-endotoxin properties by binding to bacterial lipopolysaccharide (LPS) resulting in LPS neutralization. Both dimer and tetramer seem to induce the LPS membrane disruption. | Moreover, HD5 also shows anti-endotoxin properties by binding to bacterial lipopolysaccharide (LPS) resulting in LPS neutralization. Both dimer and tetramer seem to induce the LPS membrane disruption. | ||
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| + | ===Reference=== | ||
| + | [1] Awang T, Pongprayoon P. The adsorption of human defensin 5 on bacterial membranes: simulation studies. J Mol Model. 2018 Sep 5;24(10):273. doi: 10.1007/s00894-018-3812-7. PMID: 30187138. | ||
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===Usage and Biology=== | ===Usage and Biology=== | ||
Revision as of 13:59, 19 October 2020
HD5, an antimicrobial peptide
Summary
A human antimicrobial peptide with 32 amino acids.HD5 fights against Gram-negative bacteria by disrupting and damaging the membrane and penetrating into the cytoplasm. Different oligomeric states were found to perform different degrees of antimicrobial activity. In solution, dimeric and tetrameric states are generally observed. A dimer was found to be the most active form, whereas a tetramer is the largest stable found in solution. Moreover, HD5 also shows anti-endotoxin properties by binding to bacterial lipopolysaccharide (LPS) resulting in LPS neutralization. Both dimer and tetramer seem to induce the LPS membrane disruption.
Reference
[1] Awang T, Pongprayoon P. The adsorption of human defensin 5 on bacterial membranes: simulation studies. J Mol Model. 2018 Sep 5;24(10):273. doi: 10.1007/s00894-018-3812-7. PMID: 30187138. Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]