Difference between revisions of "Part:BBa K3351003"

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<partinfo>BBa_K3351003 short</partinfo>
 
<partinfo>BBa_K3351003 short</partinfo>
 
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===Summary===
 
Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. The anionic derivative, DCD-1L, comprises of the N-terminal 47 residues of DCD and one additional leucine residue. DCD-1L is anionic, with a net charge of −5, and is amphipathic in nature. It has three helical regions and its cationic N-terminal part is proposed to interact with negatively charged phospholipid membranes of bacteria. On the bacterial membrane, studies suggest that the DCD-1L peptide first aligns flat with surface and then slowly forms oligomeric complexes, which are stabilized by Zn2+ and coordinated by the H38 residue. The oligomeric complex then breaks open, inserts into the membrane, and undergoes re-oligomerization to form the channel. The contents flow out though the channel and the bacterial die.
 
Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. The anionic derivative, DCD-1L, comprises of the N-terminal 47 residues of DCD and one additional leucine residue. DCD-1L is anionic, with a net charge of −5, and is amphipathic in nature. It has three helical regions and its cationic N-terminal part is proposed to interact with negatively charged phospholipid membranes of bacteria. On the bacterial membrane, studies suggest that the DCD-1L peptide first aligns flat with surface and then slowly forms oligomeric complexes, which are stabilized by Zn2+ and coordinated by the H38 residue. The oligomeric complex then breaks open, inserts into the membrane, and undergoes re-oligomerization to form the channel. The contents flow out though the channel and the bacterial die.
  
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===Reference===
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[1] Nguyen VS, Tan KW, Ramesh K, Chew FT, Mok YK. Structural basis for the bacterial membrane insertion of dermcidin peptide, DCD-1L. Sci Rep. 2017 Oct 24;7(1):13923. doi: 10.1038/s41598-017-13600-z. PMID: 29066724; PMCID: PMC5654962.
 
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===Usage and Biology===
 
===Usage and Biology===

Revision as of 13:58, 19 October 2020


DCD1L, an antimicrobial peptide.

Summary

Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. The anionic derivative, DCD-1L, comprises of the N-terminal 47 residues of DCD and one additional leucine residue. DCD-1L is anionic, with a net charge of −5, and is amphipathic in nature. It has three helical regions and its cationic N-terminal part is proposed to interact with negatively charged phospholipid membranes of bacteria. On the bacterial membrane, studies suggest that the DCD-1L peptide first aligns flat with surface and then slowly forms oligomeric complexes, which are stabilized by Zn2+ and coordinated by the H38 residue. The oligomeric complex then breaks open, inserts into the membrane, and undergoes re-oligomerization to form the channel. The contents flow out though the channel and the bacterial die.


Reference

[1] Nguyen VS, Tan KW, Ramesh K, Chew FT, Mok YK. Structural basis for the bacterial membrane insertion of dermcidin peptide, DCD-1L. Sci Rep. 2017 Oct 24;7(1):13923. doi: 10.1038/s41598-017-13600-z. PMID: 29066724; PMCID: PMC5654962. Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]