Difference between revisions of "Part:BBa K108021"
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global DNA-binding transcriptional dual regulator of E.coli
 
global DNA-binding transcriptional dual regulator of E.coli
  
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===Information contributed by City of London UK (2021)===
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===Usage and Biology===
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Part information is collated here to help future users of the BioBrick registry.
  
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Metadata:
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<span class='h3bb'>Sequence and Features</span>
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*'''Group:''' City of London UK 2021
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<partinfo>BBa_K108021 SequenceAndFeatures</partinfo>
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*'''Author:''' Lucas Ng
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*'''Summary:''' Added information collated from existing scientific studies
  
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fis is an activator of ribosomal RNA transcription as well as other genes, as a key part in upstream up-regulation of rRNA promoters [https://pubmed.ncbi.nlm.nih.gov/2209559]
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It binds to a recombinatorial enhancer helix-turn-helix sequence motif, facilitating hin-mediated DNA inversion [https://pubmed.ncbi.nlm.nih.gov/9362499] as well as binding to hundreds of transcriptionally active and inactive AT-rich sites [https://pubmed.ncbi.nlm.nih.gov/18340041] approximately half of which are located in non-coding DNA [https://pubmed.ncbi.nlm.nih.gov/16963779]
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It prevents the initiation of oriC-mediated DNA replication [https://pubmed.ncbi.nlm.nih.gov/8836178]
  
 
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Revision as of 11:06, 26 July 2021

Fis

global DNA-binding transcriptional dual regulator of E.coli

Information contributed by City of London UK (2021)

Part information is collated here to help future users of the BioBrick registry.

Metadata:

  • Group: City of London UK 2021
  • Author: Lucas Ng
  • Summary: Added information collated from existing scientific studies

fis is an activator of ribosomal RNA transcription as well as other genes, as a key part in upstream up-regulation of rRNA promoters [1]

It binds to a recombinatorial enhancer helix-turn-helix sequence motif, facilitating hin-mediated DNA inversion [2] as well as binding to hundreds of transcriptionally active and inactive AT-rich sites [3] approximately half of which are located in non-coding DNA [4]

It prevents the initiation of oriC-mediated DNA replication [5]