Difference between revisions of "Part:BBa K3132017"

 
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<partinfo>BBa_K3132017 parameters</partinfo>
 
<partinfo>BBa_K3132017 parameters</partinfo>
 
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==MIT MAHE 2020==
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'''Summary'''
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Interleukin-15 (IL-15) is a pleiotropic cytokine with variety of biological functions in many different cell types. It plays a major role in protective immune and inflammatory responses to microbial invaders and parasites. It is involved in modulating immune cells of both the innate and adaptive immune systems. IL-15 is a cytokine with potent survival and immunomodulatory effects on cells of both innate and adaptive immune systems. It has the ability to activate and expand NK cells, NKT cells, CD8+ effector memory and central memory T lymphocytes.
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==References==
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1. Perera, P. Y., Lichy, J. H., Waldmann, T. A., & Perera, L. P. (2012). The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use. Microbes and infection, 14(3), 247–261. https://doi.org/10.1016/j.micinf.2011.10.006

Revision as of 15:28, 20 October 2020


human interleukine 15

In order to make the monitoring device has higher sensitivity,IL-15 proteins have high secretory capability. At the same time, to reduce the interference of IL-15 proteins original expression, we fused suntag which had been well characterized in this literature and another generic protein label flag to I-15 proteins, anticipating this device can detect IL-15-tag signal molecules secreted by the core device.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI.rc site found at 296


MIT MAHE 2020

Summary

Interleukin-15 (IL-15) is a pleiotropic cytokine with variety of biological functions in many different cell types. It plays a major role in protective immune and inflammatory responses to microbial invaders and parasites. It is involved in modulating immune cells of both the innate and adaptive immune systems. IL-15 is a cytokine with potent survival and immunomodulatory effects on cells of both innate and adaptive immune systems. It has the ability to activate and expand NK cells, NKT cells, CD8+ effector memory and central memory T lymphocytes.

References

1. Perera, P. Y., Lichy, J. H., Waldmann, T. A., & Perera, L. P. (2012). The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use. Microbes and infection, 14(3), 247–261. https://doi.org/10.1016/j.micinf.2011.10.006