Difference between revisions of "Part:BBa K3282000"

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This part contains coding sequence of Escherichia coli’s K12 (substr. MG1655) arsenical resistance operon repressor (arsR, Gene ID: 948013, Uniprot: P37309) codon-optimized for Escherichia coli Nissle 1917. The arsR gene which encodes for regulatory proteins, is a part of the ars operon of the E. coli conjugal plasmid R773 (1). ArsR is a 117 residue protein, that has been shown to be a trans‐acting repressor and is a sensor of environmental As(III). This 13 kDa protein belongs to the ArsR family of metalloregulatory proteins that respond to a variety of metals including As(III), Sb(III), Cd(II), and Zn(II) (2).
 
This part contains coding sequence of Escherichia coli’s K12 (substr. MG1655) arsenical resistance operon repressor (arsR, Gene ID: 948013, Uniprot: P37309) codon-optimized for Escherichia coli Nissle 1917. The arsR gene which encodes for regulatory proteins, is a part of the ars operon of the E. coli conjugal plasmid R773 (1). ArsR is a 117 residue protein, that has been shown to be a trans‐acting repressor and is a sensor of environmental As(III). This 13 kDa protein belongs to the ArsR family of metalloregulatory proteins that respond to a variety of metals including As(III), Sb(III), Cd(II), and Zn(II) (2).
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References
 
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1. Carlin, A., Shi, W., Dey, S., Rosen, B. (1995). The ars operon of Escherichia coli confers arsenical and antimonial resistance. Journal of Bacteriology, 177 (4), 981-986; doi: 10.1128/jb.177.4.981-986.
 
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2. Rastorguev, S.M., Zavilgelsky, G.B., Tchurikov, N.A. (1998). IncI1 plasmid R64 encodes the ArsR protein that alleviates type I restriction. FEBS Lett. 426, 21–23.
 

Revision as of 18:40, 11 October 2019

This part contains coding sequence of Escherichia coli’s K12 (substr. MG1655) arsenical resistance operon repressor (arsR, Gene ID: 948013, Uniprot: P37309) codon-optimized for Escherichia coli Nissle 1917. The arsR gene which encodes for regulatory proteins, is a part of the ars operon of the E. coli conjugal plasmid R773 (1). ArsR is a 117 residue protein, that has been shown to be a trans‐acting repressor and is a sensor of environmental As(III). This 13 kDa protein belongs to the ArsR family of metalloregulatory proteins that respond to a variety of metals including As(III), Sb(III), Cd(II), and Zn(II) (2).