Difference between revisions of "Part:BBa K2534004:Design"

Latest revision as of 12:26, 17 October 2018

mIRNA 134 3p

miRNA-134 has been discovered to function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling. [http://2018.igem.org/Team:AFCM-Egypt# Team:AFCM-Egypt 2018] worked to do lentiviral transfection of that part into colorectal cancer cell line RKO to induce regulatory apoptosis as well as to investigate it's immune modulatory effect on TLR-9. [http://2018.igem.org/Team:AFCM-Egypt# Team:AFCM-Egypt 2018] have characterized this part considering it's apoptotic effect of RKO cell lines.

For further information about demonstration of its apoptotic effect, please visit our results page http://2018.igem.org/Team:AFCM-Egypt/Demonstrate

This parts has been structurally modeled for more information, please visit our modeling page http://2018.igem.org/Team:AFCM-Egypt/Model

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

Design Notes

This part has been synthesized through IDT offer

Source

http://2018.igem.org/Team:AFCM-Egypt/Bioinformatics_Page_link

@@ Line 3: / Line 3: @@
 <partinfo>BBa_K2534004 short</partinfo>
-miRNA-134 5p has been discovered to function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling.
+miRNA-134 has been discovered to function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling.
 [http://2018.igem.org/Team:AFCM-Egypt# Team:AFCM-Egypt 2018] worked to do lentiviral transfection of that part into colorectal cancer cell line RKO to induce regulatory apoptosis as well as to investigate it's immune modulatory effect on TLR-9.
 [http://2018.igem.org/Team:AFCM-Egypt# Team:AFCM-Egypt 2018] have characterized this part considering it's apoptotic effect of RKO cell lines.