Latest revision as of 13:37, 15 October 2018

Promoter ent Actived Intracelluraly in Salmonella

Gene ent located in the cluster of enterobactin (ent) genes. In respond to iron deprivation, Salmonella enterica serovar Typhimurim secretes siderophores and enterobactin in SCV condition to sense and adapt to the intracellular environment of different types of host cells.

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Reference

1. Crouch, M. L. V, Castor, M., Karlinsey, J. E., Kalhorn, T. & Fang, F. C. Biosynthesis and IroC-dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium. Mol. Microbiol. 67, 971–983 (2008). 2.Liu, J., Walsh, C. T., Liu, J., Quinn, N. & Berchtold, G. A. Overexpression, Purification, and Characterization of Isochorismate Synthase (EntC), the First Enzyme Involved in the Biosynthesis of Enterobactin from Chorismate. Biochemistry29, 1417–1425 (1990). 3. Hautefort, I. et al. During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems. Cell. Microbiol. 10, 958–984 (2008).