Difference between revisions of "Part:BBa K2588006"

Revision as of 22:50, 17 October 2018

Cell division inhibitor cbtA

CbtA is a cytoskeleton toxin from E. coli. It is the third part in our growth inhibition module. We decided to use this component of the type IV toxin-antitoxin system, because it interacts with FtsZ and MreB. Both proteins are involved in the elongation of E. coli during cell division as well as for building of the F-ring, to divide the cell.

Usage and Biology

CbtA inhibits the polymerization of FtsZ and MreB by binding to them and therefore inhibits cell division.¹

References

Tan, Q., Awano, N. & Inouye, M. YeeV is an Escherichia coli toxin that inhibits cell division by targeting the cytoskeleton proteins, FtsZ and MreB. Mol. Microbiol. 79, 109–118 (2011).

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

@@ Line 3: / Line 3: @@
 <partinfo>BBa_K2588006 short</partinfo>
-Coming soon
+<html>
+<p>CbtA is a cytoskeleton toxin from <i>E. coli</i>. It is the third part in our growth inhibition module. We decided to use this component of the type IV toxin-antitoxin system, because it interacts with FtsZ and MreB. Both proteins are involved in the elongation of <i>E. coli</i> during cell division as well as for building of the F-ring, to divide the cell.</p>
+<h2>Usage and Biology</h2>
+<p>CbtA inhibits the polymerization of FtsZ and MreB by binding to them and therefore inhibits cell division.<sup>1</sup>
+<h2>References</h2>
+<ol>
+<li>Tan, Q., Awano, N. & Inouye, M. YeeV is an Escherichia coli toxin that inhibits cell division by targeting the cytoskeleton proteins, FtsZ and MreB. <i>Mol. Microbiol</i>. <b>79</b>, 109–118 (2011).<li>
+</ol>
+</html>
 <!-- Add more about the biology of this part here