Difference between revisions of "Part:BBa K1800000"
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<h2 style="margin-left: 0cm; text-indent: 0cm; font-weight: bold; font-size: 24px;">Brief introduction | <h2 style="margin-left: 0cm; text-indent: 0cm; font-weight: bold; font-size: 24px;">Brief introduction | ||
of Mambalgin Protein</h2> | of Mambalgin Protein</h2> | ||
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This codes for the peptide Mambalgin-1, an analgesic. Mambalgin is a protein component of the venom of Dendroaspis polylepis, better known as the Black Mamba. Mambalgin-1 peptide that is a powerful analgesic that directly blocks pain transmission in the peripheral nervous system (Diochot et al, 2012) by targeting acid-sensing ion channels within nociceptors beneath the epidermis. Because Mambalgin acts on pain receptors within the skin rather than on opioid receptors in the brain, this peptide has great potential as a medication for pain treatment that is non-addicting and non-habit forming. Furthermore, recombinant purification of Mambalgin could assist in developing anti-venom without the attendant risk of harvesting venom directly from snakes. This part is designed for expression in E. coli. | This codes for the peptide Mambalgin-1, an analgesic. Mambalgin is a protein component of the venom of Dendroaspis polylepis, better known as the Black Mamba. Mambalgin-1 peptide that is a powerful analgesic that directly blocks pain transmission in the peripheral nervous system (Diochot et al, 2012) by targeting acid-sensing ion channels within nociceptors beneath the epidermis. Because Mambalgin acts on pain receptors within the skin rather than on opioid receptors in the brain, this peptide has great potential as a medication for pain treatment that is non-addicting and non-habit forming. Furthermore, recombinant purification of Mambalgin could assist in developing anti-venom without the attendant risk of harvesting venom directly from snakes. This part is designed for expression in E. coli. | ||
Revision as of 06:32, 29 October 2016
Mambalgin-1 for E. coli
Brief introduction of Mambalgin Protein
This codes for the peptide Mambalgin-1, an analgesic. Mambalgin is a protein component of the venom of Dendroaspis polylepis, better known as the Black Mamba. Mambalgin-1 peptide that is a powerful analgesic that directly blocks pain transmission in the peripheral nervous system (Diochot et al, 2012) by targeting acid-sensing ion channels within nociceptors beneath the epidermis. Because Mambalgin acts on pain receptors within the skin rather than on opioid receptors in the brain, this peptide has great potential as a medication for pain treatment that is non-addicting and non-habit forming. Furthermore, recombinant purification of Mambalgin could assist in developing anti-venom without the attendant risk of harvesting venom directly from snakes. This part is designed for expression in E. coli.
Sequence and Features
BBa_K1800000 SequenceAndFeatures