Difference between revisions of "Part:BBa K2052018"

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Butyryl-CoA:acetate CoA-transferase

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Usage and Biology

ButCoaT is an enzyme (Butyryl-CoA:acetate CoA-transferase) (EC 2.8.3.8) (Uniprot: C7GB37) that can be found in Roseburia intestinalis L1-82. ButCoaT’s main function iS to convert Acetyl-CoA to Butyrate. The pathway of the reaction (acyl-CoA:acetate CoA-transferase) ( KEGG Reaction No. : R01179 ) is given down below : Butanoyl-CoA + Acetate <=> Butanoic acid + Acetyl-CoA

Butyrate

Butyrate is a four carbon, short chain fatty acid that inhibits cancer. It induces apoptosis and differentiation, inhibits proliferation of tumorous cells in colon flora. It is produced by the bacterial fermantation of carbohydrates in colon. Butyrate is formed by many pathways that begin with glutarate, Acetyl-CoA and Lysine as it is seen in the picture below. Acetyl-CoA is readily present in the cells so we want to find an enzyme that directly converts it to our treatment, Butyrate which is ButCoAT

Sequence and Features