Difference between revisions of "Part:BBa K1604030"
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<i>pncB</i> encodes for the enzyme NAPRTase (nicotinic acid phosphoribosyl-transferase). | <i>pncB</i> encodes for the enzyme NAPRTase (nicotinic acid phosphoribosyl-transferase). | ||
− | It catalyzes the formation of nicotinate mono-nucleotide, a direct precursor of NAD, from NA. | + | It catalyzes the formation of nicotinate mono-nucleotide, a direct precursor of NAD, from NA.<html><a href="#fn:1" id="fnref:1" title="see footnote" class="footnote">[1]</a></html> <html><a href="#fn:2" id="fnref:1" title="see footnote" class="footnote">[2]</a></html> <html><a href="#fn:3" id="fnref:1" title="see footnote" class="footnote">[3]</a></html>. |
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<div style="text-align:center"><html><img src="https://static.igem.org/mediawiki/parts/e/ed/Unitn_pics_2015_NADpathway.png" style="width:75%;"></img></div></html> | <div style="text-align:center"><html><img src="https://static.igem.org/mediawiki/parts/e/ed/Unitn_pics_2015_NADpathway.png" style="width:75%;"></img></div></html> | ||
<p style="width:600px; margin-left:150px; margin-bottom:60px; | <p style="width:600px; margin-left:150px; margin-bottom:60px; | ||
− | text-align:justify "><b>FIGURE 1. Biochemical pathway of NAD synthesis.</b> PncB gene encodes the transcription of the NARPTase which catalyzes the formation of nicotinate mono-nucleotide from nicotinic acid.</p> | + | text-align:justify "><b>FIGURE 1. Biochemical pathway of NAD synthesis.</b> PncB gene encodes the transcription of the NARPTase which catalyzes the formation of nicotinate mono-nucleotide from nicotinic acid. This is considered the limiting step of the synthesis of NAD. </p> |
+ | <div class="footnotes"> | ||
+ | <hr /> | ||
+ | <ol> | ||
+ | <li id="fn:1"> | ||
+ | <p>Susana J. Berrıos-Rivera, K.-Y. San, and G. N. Bennett. (2002) Metabolic Engineering 4, 238–247</p> | ||
+ | </li> | ||
+ | |||
+ | <li id="fn:2"> | ||
+ | <p>Marcel G. Wubbolts, Peter Terpstra, Jan B. van Beilen, Jaap Kingma, H. A. Rene Meesters, and Bernard Witholt. (1990) JBC, 265 (29), 17665-72</p> | ||
+ | </li> | ||
+ | |||
+ | <li id="fn:3"> | ||
+ | <p>Ka-Yiu San, George N. Bennett, Susana J. Berríos-Rivera, Ravi V. Vadali, Yea-Tyng Yang, Emily Horton, Fred B. Rudolph, Berna Sariyar, and Kimathi Blackwood (2002) Metabolic Engineering, 4, 182–192</p> | ||
+ | </li> | ||
+ | |||
+ | </ol> | ||
+ | </div> | ||
+ | </html> | ||
+ | <!-- --> | ||
<span class='h3bb'>Sequence and Features</span> | <span class='h3bb'>Sequence and Features</span> | ||
<partinfo>BBa_K1604030 SequenceAndFeatures</partinfo> | <partinfo>BBa_K1604030 SequenceAndFeatures</partinfo> |
Revision as of 15:48, 9 September 2015
pncB
pncB encodes for the enzyme NAPRTase (nicotinic acid phosphoribosyl-transferase). It catalyzes the formation of nicotinate mono-nucleotide, a direct precursor of NAD, from NA.[1] [2] [3].
Usage and Biology
FIGURE 1. Biochemical pathway of NAD synthesis. PncB gene encodes the transcription of the NARPTase which catalyzes the formation of nicotinate mono-nucleotide from nicotinic acid. This is considered the limiting step of the synthesis of NAD.
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Susana J. Berrıos-Rivera, K.-Y. San, and G. N. Bennett. (2002) Metabolic Engineering 4, 238–247
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Marcel G. Wubbolts, Peter Terpstra, Jan B. van Beilen, Jaap Kingma, H. A. Rene Meesters, and Bernard Witholt. (1990) JBC, 265 (29), 17665-72
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Ka-Yiu San, George N. Bennett, Susana J. Berríos-Rivera, Ravi V. Vadali, Yea-Tyng Yang, Emily Horton, Fred B. Rudolph, Berna Sariyar, and Kimathi Blackwood (2002) Metabolic Engineering, 4, 182–192
</html> Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 1106
- 1000COMPATIBLE WITH RFC[1000]