Difference between revisions of "Part:BBa K892405"

Latest revision as of 16:34, 3 October 2012

HB80.4 starting varient

The starting HB80.4 flu binder originally shown to bind to various subtypes of Hemagglutinin in group 1. Originally identifited by Fleishman et al., further optimized by Whitehead et al.

Usage and Biology

This binder is known to bind to multiple HA subtypes in group 1. See papers for more details:

[1] Whitehead, Timothy, et al. "Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing." Nature Biotechnology 30.6 (2012):543-548.

[2] Fleishman, Sarel, et al."Computational design of proteins targeting the conserved stem region of influenza hemagglutinin." Science 332.6031 (2011): 816-821.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
INCOMPATIBLE WITH RFC[21]
Illegal XhoI site found at 166
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

@@ Line 1: / Line 1: @@
 __NOTOC__
 <partinfo>BBa_K892405 short</partinfo>
-Designed hemagglutinin binding protein
+The starting HB80.4 flu binder originally shown to bind to various subtypes of Hemagglutinin in group 1. Originally identifited by Fleishman et al., further optimized by Whitehead et al.
-<!-- Add more about the biology of this part here
 ===Usage and Biology===
+This binder is known to bind to multiple HA subtypes in group 1. See papers for more details:
+[1] Whitehead, Timothy, et al. "Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing." Nature Biotechnology 30.6 (2012):543-548.
+[2] Fleishman, Sarel, et al."Computational design of proteins targeting the conserved stem region of influenza hemagglutinin." Science 332.6031 (2011): 816-821.
 <!-- -->