Difference between revisions of "Part:BBa K909015"

Latest revision as of 01:13, 27 September 2012

p-ABA overproduction composite without promoter

p-ABA is derived from the aromatic branch point precursor chorismate in two steps. Aminodeoxychorismate (ADC) synthase converts chorismate and glutamine to ADC and glutamate. The conversion of chorismate and glutamine to ADC and glutamate determines the rate and therefore overexpression of ADC synthase leads to overproduction of p-ABA. ADC synthase is composed of two subunits, PabA and PabB/C. Finally ADC lyase removes pyruvate from ADC, aromatizes the ring, and generates p-ABA.

pABA is synthesized from chorismate in a 2-step process unsing pabA, pabB and pabC. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855612/ Wegkamp et al.]

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

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 p-ABA is derived from the aromatic branch point precursor chorismate in two steps. Aminodeoxychorismate (ADC) synthase converts chorismate and glutamine to ADC and glutamate. The conversion of chorismate and glutamine to ADC and glutamate determines the rate and therefore overexpression of ADC synthase leads to overproduction of p-ABA. ADC synthase is composed of two subunits, PabA and PabB/C. Finally ADC lyase removes pyruvate from ADC, aromatizes the ring, and generates p-ABA.
+[[Image:Wegkamp Chorismate.png|600px|center|thumb|pABA is synthesized from chorismate in a 2-step process unsing pabA, pabB and pabC. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855612/ Wegkamp et al.]]]
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