Difference between revisions of "Part:BBa K861050"
Line 2: | Line 2: | ||
<partinfo>BBa_K861050 short</partinfo> | <partinfo>BBa_K861050 short</partinfo> | ||
− | FadR is a transcription regulator, which, when not binds to acyl-CoA can either serve as an activator for fatty acid | + | FadR is a transcription regulator, which, when not binds to acyl-CoA can either serve as an activator for fatty acid synthesis gene like FabA, FabB and etc. or a repressor for fatty acid degradation gene like FadA, FadB, FadD and etc. After long chain fatty acid is converted to fatty acyl- CoA by FadD, it can bind to FadR. This binding will alter the conformation of FadR, making it unable to bind to the DNA sequence it recognizes. To our knowledge, there is no promoter exists in nature that can respond solely to FadR since those promoters are often regulated by glucose concentration or oxidative stress and many other factors. |
<!-- Add more about the biology of this part here | <!-- Add more about the biology of this part here |
Revision as of 08:58, 22 September 2012
FadR, fatty acid sensor from E.coli str. K12
FadR is a transcription regulator, which, when not binds to acyl-CoA can either serve as an activator for fatty acid synthesis gene like FabA, FabB and etc. or a repressor for fatty acid degradation gene like FadA, FadB, FadD and etc. After long chain fatty acid is converted to fatty acyl- CoA by FadD, it can bind to FadR. This binding will alter the conformation of FadR, making it unable to bind to the DNA sequence it recognizes. To our knowledge, there is no promoter exists in nature that can respond solely to FadR since those promoters are often regulated by glucose concentration or oxidative stress and many other factors.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]