Difference between revisions of "Part:BBa K733004"
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<partinfo>BBa_K733004 short</partinfo> | <partinfo>BBa_K733004 short</partinfo> | ||
| − | + | ydcE which also is named as ndoA, encoding an RNase, namely EndoA. Being in the same RNase family with MazF/ChpAK/PemK, YdcE - the endoribonuclease ydcE encodes - can inactivate cellular mRNAs by cleaving them at specific but frequently occurring sites (i.e. UAUAAU↓AC). Thus, overexpression of EndoA can lead to programmed cell death or unhealthy conditions, depending on the amount of EndoA. Note that ydcE(ndoA) is demonstrated functional both in E. coli and B. subtilis. (Pellegrini et al., 2005) | |
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| + | [[Image:YdcE.png]] | ||
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<partinfo>BBa_K733004 parameters</partinfo> | <partinfo>BBa_K733004 parameters</partinfo> | ||
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| + | ==Reference== | ||
| + | Pellegrini O, Mathy N, Gogos A, Shapiro L, and Condon C. "The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor.." Molecular microbiology. 56.5 (2005): 1139-1148. Print. | ||
Revision as of 17:08, 22 September 2012
RBS+ydcE
ydcE which also is named as ndoA, encoding an RNase, namely EndoA. Being in the same RNase family with MazF/ChpAK/PemK, YdcE - the endoribonuclease ydcE encodes - can inactivate cellular mRNAs by cleaving them at specific but frequently occurring sites (i.e. UAUAAU↓AC). Thus, overexpression of EndoA can lead to programmed cell death or unhealthy conditions, depending on the amount of EndoA. Note that ydcE(ndoA) is demonstrated functional both in E. coli and B. subtilis. (Pellegrini et al., 2005)
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Reference
Pellegrini O, Mathy N, Gogos A, Shapiro L, and Condon C. "The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor.." Molecular microbiology. 56.5 (2005): 1139-1148. Print.