Difference between revisions of "Part:BBa K847004"

Revision as of 23:57, 3 October 2012

''Deinococcus radiodurans'' Superoxide dismutase, SodCu/Zn

Deinococcus radiodurans is an extremely radiation-resistant bacterium: while about 10 Gy (absorbed radiation dose, Gray) can kill most vertebrates, D. radiodurans can withstand up to 12,000 Gy. Current literature supports this finding with D. radiodurans’ unique genetic makeup which allows it to better handle radiation exposure. The two main effects of radiation exposure to bacterial cells are DNA damage and the creation of toxic superoxide species (Daly 2009). Two DNA damage prevention and repair proteins in D. radiodurans have been shown to outperform analogs in less radiation-tolerant bacteria. To take care of the pesky superoxides, superoxide dismutases are expressed in high levels in D. radiodurans (Slade and Miroslav 2011). These enzymes break the reactive species down into harmless oxygen and hydrogen peroxides. This dismutase uses copper and zinc as cofactors (Gao, Zhang, Song, Chen, and Zhong 2009).

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
INCOMPATIBLE WITH RFC[25]
Illegal NgoMIV site found at 389
Illegal NgoMIV site found at 496
1000
COMPATIBLE WITH RFC[1000]

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 __NOTOC__
 <partinfo>BBa_K847004 short</partinfo>
-tba
+''Deinococcus radiodurans'' is an extremely radiation-resistant bacterium: while about 10 Gy (absorbed radiation dose, Gray) can kill most vertebrates, ''D. radiodurans'' can withstand up to 12,000 Gy. Current literature supports this finding with ''D. radiodurans’'' unique genetic makeup which allows it to better handle radiation exposure. The two main effects of radiation exposure to bacterial cells are DNA damage and the creation of toxic superoxide species (Daly 2009). Two DNA damage prevention and repair proteins in ''D. radiodurans'' have been shown to outperform analogs in less radiation-tolerant bacteria. To take care of the pesky superoxides, superoxide dismutases are expressed in high levels in ''D. radiodurans'' (Slade and Miroslav 2011). These enzymes break the reactive species down into harmless oxygen and hydrogen peroxides. This dismutase uses copper and zinc as cofactors (Gao, Zhang, Song, Chen, and Zhong 2009).
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-===Usage and Biology===
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