Difference between revisions of "Part:BBa K364309"

Latest revision as of 21:03, 26 October 2010

Human ER LBD

ER-α is a 17β-estradiol-activated steroid receptor member of the nuclear receptor superfamily of transcription factors. It has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems. ER-α is expressed at low to moderate levels in major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, immune, reproductive, cardiovascular, respiratory and structural), with peaks of expression in the pituitary, ovary, uterus and vas deferens. ER-α dysfunction is associated with cancer, cardiovascular system defects, hematological system defects, immune and inflammation diseases, metabolic defects, reproductive defects.

More on ER here: [http://en.wikipedia.org/wiki/Estrogen_receptor].

ER Uniprot: [http://www.uniprot.org/uniprot/P03372].

View ER LBD crystal structure here: [http://www.rcsb.org/pdb/explore/jmol.do?structureId=2QGT&bionumber=1].

Crystal structure of the estrogen receptor alpha ligand binding domain complexed with an ether estradiol compound

Description of the ER LBD LBD crystal structure with reference here: [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659626/?tool=pubmed].

Picture of gel electrophoresis: ER LBD in pSB1C3 results a 828 bp long insert.

Sequence and Features