Difference between revisions of "Part:BBa K364310:Experience"

(Physiological effects of EcR)
(Ligand)
 
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===Ligand===
 
===Ligand===
  
Ecdysteroids (EcR)
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Ecdysteroids
 
   
 
   
 
Ecdysteroids  are  insect  moulting  and  sex  hormones  which  include  ecdysone  and  
 
Ecdysteroids  are  insect  moulting  and  sex  hormones  which  include  ecdysone  and  

Latest revision as of 01:56, 26 October 2010

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Ligand

Ecdysteroids

Ecdysteroids are insect moulting and sex hormones which include ecdysone and its homologues such as 20-hydroxyecdysone. Ecdysteroids also occur in other invertebrates where they can play a different role. They also appear in many plants mostly as a protection agents (toxins or antifeedants) against herbivore insects. These phytoecdysteroids have medicinal value and are part of herbal adaptogenic remedies like cordyceps.

Physiological effects of EcR

Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes, as evidenced by chromosomal puffing at over a hundred sites. Ultimately the activation cascade causes physiological changes that result in ecdysis (moulting).

Potential applications of EcR LBD

EcR LBD can be fused with different DBDs in order to activate downstream gene expression depending on the binding site of the DBD.

Applications of BBa_K364310

User Reviews

UNIQ5e3011d366b30239-partinfo-00000000-QINU UNIQ5e3011d366b30239-partinfo-00000001-QINU