Difference between revisions of "Part:BBa K364310:Experience"
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Ecdysteroids are insect moulting and sex hormones which include ecdysone and | Ecdysteroids are insect moulting and sex hormones which include ecdysone and | ||
Latest revision as of 01:56, 26 October 2010
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how you used this part and how it worked out.
Ligand
Ecdysteroids
Ecdysteroids are insect moulting and sex hormones which include ecdysone and its homologues such as 20-hydroxyecdysone. Ecdysteroids also occur in other invertebrates where they can play a different role. They also appear in many plants mostly as a protection agents (toxins or antifeedants) against herbivore insects. These phytoecdysteroids have medicinal value and are part of herbal adaptogenic remedies like cordyceps.
Physiological effects of EcR
Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes, as evidenced by chromosomal puffing at over a hundred sites. Ultimately the activation cascade causes physiological changes that result in ecdysis (moulting).
Potential applications of EcR LBD
EcR LBD can be fused with different DBDs in order to activate downstream gene expression depending on the binding site of the DBD.
Applications of BBa_K364310
User Reviews
UNIQc9b8a8cc4d9a2df1-partinfo-00000000-QINU UNIQc9b8a8cc4d9a2df1-partinfo-00000001-QINU