Difference between revisions of "Part:BBa K364328:Experience"
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This experience page is provided so that any user may enter their experience using this part.<BR>Please enter | This experience page is provided so that any user may enter their experience using this part.<BR>Please enter | ||
how you used this part and how it worked out. | how you used this part and how it worked out. | ||
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| + | ===Ligand=== | ||
| + | The ligands of DAF-12 are various isomers of dafachronic acids, which derive from sterols upon oxidation by DAF-9, a cytochrome P450 enzime. | ||
===Physiological effects of DAF-12=== | ===Physiological effects of DAF-12=== | ||
| − | daf-12 in Caenorhabditis elegans plays a key role in the regulation of development and determination of adult longevity. It has effects also on resistance to oxidative and thermal stress which makes daf-12 the first gene with alleles that can extend or shorten lifespan. | + | daf-12 in Caenorhabditis elegans plays a key role in the regulation of development and determination of adult longevity. It has effects also on resistance to oxidative and thermal stress which makes daf-12 the first gene with alleles that can extend or shorten lifespan. |
===Possible applications of GAL4-DAF-12=== | ===Possible applications of GAL4-DAF-12=== | ||
Latest revision as of 01:44, 26 October 2010
This experience page is provided so that any user may enter their experience using this part.
Please enter
how you used this part and how it worked out.
Ligand
The ligands of DAF-12 are various isomers of dafachronic acids, which derive from sterols upon oxidation by DAF-9, a cytochrome P450 enzime.
Physiological effects of DAF-12
daf-12 in Caenorhabditis elegans plays a key role in the regulation of development and determination of adult longevity. It has effects also on resistance to oxidative and thermal stress which makes daf-12 the first gene with alleles that can extend or shorten lifespan.
Possible applications of GAL4-DAF-12
By the addition of lipid ligands (dafachronic acids), the created system activates the expression of any kind of genes fused to UAS(upstream activation seqence)previously. Also can be used as a lipid sensor by activating reporter genes (e.g. Luciferase).
Applications of BBa_K364328
User Reviews
UNIQ07ca91bffa6744a8-partinfo-00000000-QINU UNIQ07ca91bffa6744a8-partinfo-00000001-QINU