Difference between revisions of "Part:BBa K364303:Experience"
(→Physiological effect) |
(→Ligand) |
||
| (One intermediate revision by the same user not shown) | |||
| Line 2: | Line 2: | ||
This experience page is provided so that any user may enter their experience using this part.<BR>Please enter | This experience page is provided so that any user may enter their experience using this part.<BR>Please enter | ||
how you used this part and how it worked out. | how you used this part and how it worked out. | ||
| + | |||
| + | ===Ligand=== | ||
| + | The ligands of DAF-12 are various isomers of dafachronic acids, which derive from sterols upon oxidation by DAF-9, a cytochrome P450 enzime. | ||
===Physiological effects of DAF-12=== | ===Physiological effects of DAF-12=== | ||
Latest revision as of 01:45, 26 October 2010
This experience page is provided so that any user may enter their experience using this part.
Please enter
how you used this part and how it worked out.
Ligand
The ligands of DAF-12 are various isomers of dafachronic acids, which derive from sterols upon oxidation by DAF-9, a cytochrome P450 enzime.
Physiological effects of DAF-12
daf-12 in Caenorhabditis elegans plays a key role in the regulation of development and determination of adult longevity. It has effects also on resistance to oxidative and thermal stress which makes daf-12 the first gene with alleles that can extend or shorten lifespan.
Possible applications od DAF-12 LBD
DAF-12 LBD can be fused with various DBDs to activate the expression of chosen genes by addition of dafachronic acids (ligand).
Applications of BBa_K364303
User Reviews
UNIQd606c8be3eb191d9-partinfo-00000000-QINU UNIQd606c8be3eb191d9-partinfo-00000001-QINU