Difference between revisions of "Part:BBa K364307"

Latest revision as of 19:56, 26 October 2010

Human ER DBD

Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol (estrogen) , which is a member of the nuclear hormone family of intracellular receptors. The main function of the estrogen receptor is as a DNA-binding transcription factor that regulates gene expression. It has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems.

More on ER here: [http://en.wikipedia.org/wiki/Estrogen_receptor].

ER Uniprot: [http://www.uniprot.org/uniprot/P03372].

View the ER DBD crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1HCQ&bionumber=1].

Picture of human ER DNA binding domain.

Description of the ER DBD crystal structure with reference here: [http://www.cell.com/retrieve/pii/009286749390390C].

Picture of gel electrophoresis: ER DBD in pSB1C3 resulting an insert of 318 bp.

Sequence and Features

Assembly Compatibility:

10
COMPATIBLE WITH RFC[10]
12
COMPATIBLE WITH RFC[12]
21
COMPATIBLE WITH RFC[21]
23
COMPATIBLE WITH RFC[23]
25
COMPATIBLE WITH RFC[25]
1000
COMPATIBLE WITH RFC[1000]

@@ Line 2: / Line 2: @@
 <partinfo>BBa_K364307 short</partinfo>
-Estrogen receptor refers to a group of receptors that are activated by the hormone 17&#946;-estradiol[1] (estrogen) , which is a member of the nuclear hormone family of intracellular receptors.
+Estrogen receptor refers to a group of receptors that are activated by the hormone 17&#946;-estradiol (estrogen) , which is a member of the nuclear hormone family of intracellular receptors. The main function of the estrogen receptor is as a DNA-binding transcription factor that regulates gene expression. It has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems.
-The main function of the estrogen receptor is as a DNA-binding transcription factor that regulates gene expression.
+More on ER here: [http://en.wikipedia.org/wiki/Estrogen_receptor].
+ER Uniprot: [http://www.uniprot.org/uniprot/P03372].
+View the ER DBD crystal structure here: [http://www.pdb.org/pdb/explore/jmol.do?structureId=1HCQ&bionumber=1].
+[[Image:ER-DBD.jpg|800px|thumb|center|Picture of human ER DNA binding domain.]]
+Description of the ER DBD crystal structure with reference here: [http://www.cell.com/retrieve/pii/009286749390390C].
+[[Image:ERdbd.jpg|800px|thumb|center|Picture of gel electrophoresis: ER DBD in pSB1C3 resulting an insert of 318 bp.]]
-[[Image:ER-DBD.jpg]]
-[[Image:Erlbd.jpg]]
 <!-- Add more about the biology of this part here