Difference between revisions of "Part:BBa K364301"

Latest revision as of 10:15, 13 August 2010

hPUMA

PUMA

Sequence and Features

Assembly Compatibility:

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 <!-- Add more about the biology of this part here
-===Usage and Biology===
+===Usage and Biology===PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2 family
+member and a critical mediator of p53-dependent and -independent apoptosis induced by a wide
+variety of stimuli, including genotoxic stress, deregulated oncogene expression, toxins, altered
+redox status, growth factor/cytokine withdrawal and infection.PUMA transduces death signals primarily to the mitochondria, where it acts indirectly on the Bcl-2 family members Bax and/or Bak by relieving the inhibition imposed by antiapoptotic members. It directly binds and antagonizes all known antiapoptotic Bcl-2 family members to
+induce mitochondrial dysfunction and caspase activation. PUMA ablation or inhibition leads to
+apoptosis deficiency underlying increased risks for cancer development and therapeutic resistance.
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