Difference between revisions of "Part:BBa K5477019"

 
 
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<partinfo>BBa_K5477019 short</partinfo>
 
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CYP1A1 (Cytochrome P450 1A1) is a vital enzyme in the cytochrome P450 family that primarily metabolizes environmental toxins, including polycyclic aromatic hydrocarbons (PAHs), dioxins, and polychlorinated biphenyls (PCBs). Predominantly expressed in the lungs and liver, CYP1A1 plays a key role in phase I metabolism, where it oxidizes hydrophobic compounds, rendering them more polar and easier to excrete. CYP1A1 catalyzes the incorporation of an oxygen atom into its substrates, producing reactive intermediates that are often further processed by phase II enzymes like UGT1A1 through glucuronidation. By metabolizing these carcinogenic and mutagenic compounds, CYP1A1 helps protect the body from toxic environmental exposures.
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CYP1A1 (Cytochrome P450 1A1) is an enzyme in the cytochrome P450 family (CYPs). CYP1A1 plays a role in phase I metabolism by catalyzing oxygenation of the substrates, producing reactive intermediates that are often further processed by phase II enzymes (3).  
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CYP1A1 metabolizes environmental toxins, including dioxins and polychlorinated biphenyls (PCBs) (1) (2).
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CYP1A1 is integrated into a detoxification module where it initiates the oxidative breakdown of harmful pollutants. This part was combined with POR, that provides the reducing power to CYPs, in the composites. The following composites and devices, where this part was used, are listed below: [https://parts.igem.org/Part:BBa_K5477037  BBa_K5477037] and [https://parts.igem.org/Part:BBa_K5477047  BBa_K5477047]
  
  
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<partinfo>BBa_K5477019 parameters</partinfo>
 
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===References===
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1. Grimm FA, Hu D, Kania-Korwel I, Lehmler HJ, Ludewig G, Hornbuckle KC, et al. Metabolism and metabolites of polychlorinated biphenyls. Crit Rev Toxicol. 2015 Mar;45(3):245–72.
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2. Inui H, Itoh T, Yamamoto K, Ikushiro S, Sakaki T. Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls. Int J Mol Sci. 2014 Aug 13;15(8):14044-57. doi: 10.3390/ijms150814044. PMID: 25123135; PMCID: PMC4159838.
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3. Liu J, Tan Y, Song E, Song Y. A Critical Review of Polychlorinated Biphenyls Metabolism, Metabolites, and Their Correlation with Oxidative Stress. Chem Res Toxicol. 2020 Aug 17;33(8):2022–42.

Latest revision as of 00:05, 2 October 2024


CYP1A1 - Cytochrome P450 1A1 from Rattus norvegicus

CYP1A1 (Cytochrome P450 1A1) is an enzyme in the cytochrome P450 family (CYPs). CYP1A1 plays a role in phase I metabolism by catalyzing oxygenation of the substrates, producing reactive intermediates that are often further processed by phase II enzymes (3). CYP1A1 metabolizes environmental toxins, including dioxins and polychlorinated biphenyls (PCBs) (1) (2).

CYP1A1 is integrated into a detoxification module where it initiates the oxidative breakdown of harmful pollutants. This part was combined with POR, that provides the reducing power to CYPs, in the composites. The following composites and devices, where this part was used, are listed below: BBa_K5477037 and BBa_K5477047


Sequence and Features


Assembly Compatibility:
  • 10
    INCOMPATIBLE WITH RFC[10]
    Illegal PstI site found at 232
    Illegal PstI site found at 1434
  • 12
    INCOMPATIBLE WITH RFC[12]
    Illegal PstI site found at 232
    Illegal PstI site found at 1434
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    INCOMPATIBLE WITH RFC[23]
    Illegal PstI site found at 232
    Illegal PstI site found at 1434
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal PstI site found at 232
    Illegal PstI site found at 1434
    Illegal NgoMIV site found at 326
    Illegal NgoMIV site found at 413
  • 1000
    COMPATIBLE WITH RFC[1000]


References

1. Grimm FA, Hu D, Kania-Korwel I, Lehmler HJ, Ludewig G, Hornbuckle KC, et al. Metabolism and metabolites of polychlorinated biphenyls. Crit Rev Toxicol. 2015 Mar;45(3):245–72.

2. Inui H, Itoh T, Yamamoto K, Ikushiro S, Sakaki T. Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls. Int J Mol Sci. 2014 Aug 13;15(8):14044-57. doi: 10.3390/ijms150814044. PMID: 25123135; PMCID: PMC4159838.

3. Liu J, Tan Y, Song E, Song Y. A Critical Review of Polychlorinated Biphenyls Metabolism, Metabolites, and Their Correlation with Oxidative Stress. Chem Res Toxicol. 2020 Aug 17;33(8):2022–42.