Difference between revisions of "Part:BBa K133071"
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UreB is a member of the metallo-dependent hydrolases superfamily and requires a nickel (Ni) cation as a cofactor to perform its enzymatic activity. Each subunit of UreB associates with two nickel ions. | UreB is a member of the metallo-dependent hydrolases superfamily and requires a nickel (Ni) cation as a cofactor to perform its enzymatic activity. Each subunit of UreB associates with two nickel ions. | ||
Latest revision as of 14:05, 25 September 2024
UreB
Urease B (UreB) is one of the main H. pylori antigens. It is a subunit of enzyme urease, composed of A and B subunit that neutralizes the pH around the microorganism by decomposing urea into ammonia and carbon dioxide, thus enabling H. pylori to survive in the acidic gastric environment. Application of this antigen should elicit production of neutralizing antibodies thus inhibiting enzymatic activity of urease, which could lead to the eventual eradication of bacteria.
Additional Information
CUHK-HongKong-SBS 2024
UreB is a member of the metallo-dependent hydrolases superfamily and requires a nickel (Ni) cation as a cofactor to perform its enzymatic activity. Each subunit of UreB associates with two nickel ions.
References
1. UniProt. (2024). Q9AFB1 · Q9AFB1_HELPX. Uniprot.org. https://www.uniprot.org/uniprotkb/Q9AFB1/entry
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21INCOMPATIBLE WITH RFC[21]Illegal BamHI site found at 1013
- 23COMPATIBLE WITH RFC[23]
- 25INCOMPATIBLE WITH RFC[25]Illegal AgeI site found at 235
Illegal AgeI site found at 1413 - 1000INCOMPATIBLE WITH RFC[1000]Illegal SapI.rc site found at 121