Difference between revisions of "Part:BBa K4165108"
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Latest revision as of 09:43, 13 October 2022
HTRA Binding Peptide 14
Part encodes for a synthetic peptide that binds to the PDZ domain of HTRA1 protein
Usage and Biology
Decameric peptide, Binds specifically to PDZ domain of HTRA1 Protein with ΔG of 3.8 ± 0.2 kcal/mol.
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
Functional Parameters
Modeling
Got score of 5 out of 6 in our Quality assessment code after modeling by AlphaFold2.0
| cbeta_deviations | clashscore | molprobity | ramachandran_favored | ramachandran_outliers | Qmean_4 | Qmean_6 |
|---|---|---|---|---|---|---|
| 0 | 0 | 1.62 | 100 | 0 | -5.843485/td> | -4.746417 |
Figure 1.: 3D Model of H1C peptide Modelled by AlphaFold2.0 displayed in Pymol.
References
Rey, J., Breiden, M., Lux, V., Bluemke, A., Steindel, M., Ripkens, K., ... & Ehrmann, M. (2022). An allosteric HTRA1-calpain 2 complex with restricted activation profile. Proceedings of the National Academy of Sciences, 119(14), e2113520119.