Difference between revisions of "Part:BBa K4165259"

 
 
(2 intermediate revisions by 2 users not shown)
Line 3: Line 3:
 
<partinfo>BBa_K4165259 short</partinfo>
 
<partinfo>BBa_K4165259 short</partinfo>
  
−
Long
+
This composite part encodes for WWW peptide which binds to misfolded tau protein  (BBa_K4165007) tagged with a GST tag (BBa_K4165070).
  
−
<!-- Add more about the biology of this part here
 
 
===Usage and Biology===
 
===Usage and Biology===
 +
 +
WWW is a synthetic peptide designed to bind to microtubule associated protein tau (MAPT) at the PHF motif which is reported to drive the accumulation of paired helical filaments form of tau resulting in tau aggregates related diseases which are mostly related to dementia. It is fused to GST tag for purification. 
 +
  
 
<!-- -->
 
<!-- -->
−
<span class='h3bb'>Sequence and Features</span>
+
===<span class='h3bb'>Sequence and Features</span>===
 
<partinfo>BBa_K4165259 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_K4165259 SequenceAndFeatures</partinfo>
  

Latest revision as of 15:08, 12 October 2022


GST-WWW

This composite part encodes for WWW peptide which binds to misfolded tau protein (BBa_K4165007) tagged with a GST tag (BBa_K4165070).

Usage and Biology

WWW is a synthetic peptide designed to bind to microtubule associated protein tau (MAPT) at the PHF motif which is reported to drive the accumulation of paired helical filaments form of tau resulting in tau aggregates related diseases which are mostly related to dementia. It is fused to GST tag for purification.


Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI.rc site found at 85