Difference between revisions of "Part:BBa K4165158"

 
 
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<partinfo>BBa_K4165158 short</partinfo>
 
<partinfo>BBa_K4165158 short</partinfo>
  
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Tau binding peptide targeting the PHF seed of Tau
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A synthetic peptide that is used for targeting misfolded tau protein (BBa_K4165009) as it binds to PHF6 of tau fibrils.
  
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===Usage and Biology===
 
===Usage and Biology===
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P-NH peptide (NITMNSRRRRNH) is tested against PHF seed of tau (<sup>306</sup>VQIVYK<sup>311</sup>) which is found in different models of tau aggregates suggesting that it has a role in the aggregation leading to Alzheimer's disease. Findings showed that P-NH can bind to PHF via van der Waal force and hydrogen bonds, it could inhibit tau hyperphosphorylation and aggregation when tested in vitro on N2a cells. In vivo, it could enhance AD mice cognitive ability.
  
 
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<span class='h3bb'>Sequence and Features</span>
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<span class='h3bb'> <p style=" font-weight: bold; font-size:17px;"> Sequence and Features</p> </span>
 
<partinfo>BBa_K4165158 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_K4165158 SequenceAndFeatures</partinfo>
  
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===References===
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1. Zhang, X., Zhang, X., Zhong, M., Zhao, P., Guo, C., Li, Y., ... & Gao, H. (2020). Selection of a d-enantiomeric peptide specifically binding to PHF6 for inhibiting Tau aggregation in transgenic mice. ACS Chemical Neuroscience, 11(24), 4240-4253. 
  
 
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Latest revision as of 15:02, 11 October 2022


P-NH

A synthetic peptide that is used for targeting misfolded tau protein (BBa_K4165009) as it binds to PHF6 of tau fibrils.

Usage and Biology

P-NH peptide (NITMNSRRRRNH) is tested against PHF seed of tau (306VQIVYK311) which is found in different models of tau aggregates suggesting that it has a role in the aggregation leading to Alzheimer's disease. Findings showed that P-NH can bind to PHF via van der Waal force and hydrogen bonds, it could inhibit tau hyperphosphorylation and aggregation when tested in vitro on N2a cells. In vivo, it could enhance AD mice cognitive ability.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    INCOMPATIBLE WITH RFC[12]
    Unknown
  • 21
    INCOMPATIBLE WITH RFC[21]
    Unknown
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Unknown
  • 1000
    COMPATIBLE WITH RFC[1000]


References

1. Zhang, X., Zhang, X., Zhong, M., Zhao, P., Guo, C., Li, Y., ... & Gao, H. (2020). Selection of a d-enantiomeric peptide specifically binding to PHF6 for inhibiting Tau aggregation in transgenic mice. ACS Chemical Neuroscience, 11(24), 4240-4253.