Difference between revisions of "Part:BBa K237004"
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RIP or RNAIII inhibiting peptide is a heptapeptide capable of severely reducing the Qourum sensing(QS) abilities of Staphylococcus species. RIP effectively works as an antibiotic in its inhibition of bacterial growth. | RIP or RNAIII inhibiting peptide is a heptapeptide capable of severely reducing the Qourum sensing(QS) abilities of Staphylococcus species. RIP effectively works as an antibiotic in its inhibition of bacterial growth. | ||
| − | RIP has the sequence YSPXTNF and has been | + | RIP has the sequence YSPXTNF and has been shown through extensive research to inhibit bacterial infections in mice in a synthetic (as in organic synthesis) form. |
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| + | The RIP produced by this generator is an export-tagged RIP brick. We used an OmpA tag, which (at least in theory) targets the peptide to the periplasmic space from where, there has been described numerous cases of leakage into the medium. Under the transport into the periplasmic space, the OmpA-leader should be cut off, leaving the RIP intact, and ready to inhibit some staph's. | ||
References will come later. | References will come later. | ||
Latest revision as of 14:35, 3 August 2009
Constitutive sRIP Generator. RIP - Quorum sensing inhibitor of Staphylococcus spp.
RIP or RNAIII inhibiting peptide is a heptapeptide capable of severely reducing the Qourum sensing(QS) abilities of Staphylococcus species. RIP effectively works as an antibiotic in its inhibition of bacterial growth.
RIP has the sequence YSPXTNF and has been shown through extensive research to inhibit bacterial infections in mice in a synthetic (as in organic synthesis) form.
The RIP produced by this generator is an export-tagged RIP brick. We used an OmpA tag, which (at least in theory) targets the peptide to the periplasmic space from where, there has been described numerous cases of leakage into the medium. Under the transport into the periplasmic space, the OmpA-leader should be cut off, leaving the RIP intact, and ready to inhibit some staph's.
References will come later.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]