Difference between revisions of "Part:BBa I712020"
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Summary: Added information collated from existing scientific studies | Summary: Added information collated from existing scientific studies | ||
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Part is involved in the activation cascade of caspases contributing to apoptosis. | Part is involved in the activation cascade of caspases contributing to apoptosis. | ||
At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond | At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond | ||
| − | Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 | + | Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. |
| − | The part is also involved in the cleavage of Huntingtin (HTT gene). | + | The part is also involved in the cleavage of Huntingtin (HTT gene). <ref>“CASP3 - Caspase-3 Precursor - Homo Sapiens (Human) - CASP3 Gene & Protein.” 2021. Uniprot.org. 2021. https://www.uniprot.org/uniprot/P42574. |
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| + | </ref> | ||
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| + | ===Activity Regulation=== | ||
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| + | Part is inhibited via isatin sulfonamides | ||
Latest revision as of 17:40, 1 October 2021
Homo sapiens caspase 3
Homo sapiens caspase 3, apoptosis-related cysteine peptidase (transcript variant beta).
Information contributed by City of London UK (2021)
Part information is collated here to help future users of the BioBrick registry.
Metadata:
Group: City of London UK 2021
Author: Julian Chen
Summary: Added information collated from existing scientific studies
Part is involved in the activation cascade of caspases contributing to apoptosis.
At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond
Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9.
The part is also involved in the cleavage of Huntingtin (HTT gene). [1]
Activity Regulation
Part is inhibited via isatin sulfonamides
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
- ↑ “CASP3 - Caspase-3 Precursor - Homo Sapiens (Human) - CASP3 Gene & Protein.” 2021. Uniprot.org. 2021. https://www.uniprot.org/uniprot/P42574.