Difference between revisions of "Part:BBa K1228004"
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'''Summary''' | '''Summary''' | ||
| − | Lactoferrin is a multifunctional protein from the transferrin group, which is assigned to serine proteases due to its enzymatic activity. In addition, lactoferrin also has nuclease activity and is an iron chelator. Lactoferrin consists of a polypeptide chain with about 700 amino acids and forms two similar globular domains called N-lobes and C-lobes, connected by a short alpha helix. Lactoferrin is one of the components of the immune system of the body; it has antimicrobial activity and is part of the innate defense. It reduces inflammation factors and thus promotes the absorption of iron into the blood and its availability in the body. | + | Lactoferrin is a multifunctional protein from the transferrin group, which is assigned to serine proteases due to its enzymatic activity. In addition, lactoferrin also has nuclease activity and is an iron chelator. Lactoferrin consists of a polypeptide chain with about 700 amino acids and forms two similar globular domains called N-lobes and C-lobes, connected by a short alpha helix. Lactoferrin is one of the components of the immune system of the body; it has antimicrobial activity and is part of the innate defense. It reduces inflammation factors and thus promotes the absorption of iron into the blood and its availability in the body. |
==References== | ==References== | ||
Latest revision as of 17:36, 23 October 2020
A fragment of loctoferrin
Lactoferrin (Lf) is a multifunctional member of the transferrin. Lf is found at the mucosal surface where it functions as a prominent component of the first line of the host defense system against infection and inflammation. This part is coding for 25 aminacid peptide that is a part of Lactoferrin. This peptide has a broad spectrum of anti-infection and anti-inflammatory function. Also, lactoferrin has a broad anti-bacterial range and strong anti-bacterial activity.
Sequence and Features
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
MIT_MAHE 2020
Summary
Lactoferrin is a multifunctional protein from the transferrin group, which is assigned to serine proteases due to its enzymatic activity. In addition, lactoferrin also has nuclease activity and is an iron chelator. Lactoferrin consists of a polypeptide chain with about 700 amino acids and forms two similar globular domains called N-lobes and C-lobes, connected by a short alpha helix. Lactoferrin is one of the components of the immune system of the body; it has antimicrobial activity and is part of the innate defense. It reduces inflammation factors and thus promotes the absorption of iron into the blood and its availability in the body.
References
1. Legrand, D., Elass, E., Carpentier, M., & Mazurier, J. (2005). Lactoferrin: a modulator of immune and inflammatory responses. Cellular and molecular life sciences : CMLS, 62(22), 2549–2559. https://doi.org/10.1007/s00018-005-5370-2
2. Ward, P. P., Paz, E., & Conneely, O. M. (2005). Multifunctional roles of lactoferrin: a critical overview. Cellular and molecular life sciences : CMLS, 62(22), 2540–2548. https://doi.org/10.1007/s00018-005-5369-8
3. Iyer, S., & Lönnerdal, B. (1993). Lactoferrin, lactoferrin receptors and iron metabolism. European journal of clinical nutrition, 47(4), 232–241. "