Difference between revisions of "Part:BBa K3117020"
 
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<partinfo>BBa_K3117020 short</partinfo>
 
<partinfo>BBa_K3117020 short</partinfo>
  
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Part BBa_K3117020 is a single chain variable fragment (scFv) of the anti-CD3 antibody. This fragment was used to generate a fusion protein to create a bispecific antibody on the one hand driected against CD3, on the other part against GPA33.
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Part BBa_K3117020 is a single chain variable fragment (scFv) of the anti-CD3 antibody. This fragment was used to generate a fusion protein to create a bispecific antibody on the one hand directed against CD3, on the other part against GPA33.
  
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===Usage and Biology===
 
===Usage and Biology===
  
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CD3 is co-expressed with the T cell receptor on T cells. Binding leads to downstream signaling cascades and activation of the T cell.  
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CD3 is co-expressed with the T cell receptor on T cells. Binding leads to downstream signaling cascades and activation of the T cell (Chetty et al., 1994).
  
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===References===
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<span class='h3bb'>Sequence and Features</span>
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<partinfo>BBa_K3117020 SequenceAndFeatures</partinfo>
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1. Chetty, R.; Gatter, K. (1994): CD3: structure, function, and role of immunostaining in clinical practice. In: The Journal of pathology 173 (4), S. 303–307. DOI: 10.1002/path.1711730404.
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===Functional Parameters===
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<partinfo>BBa_K3117020 parameters</partinfo>
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Latest revision as of 23:04, 21 October 2019


scFv VH against CD3 codon optimized for CHO expression

Part BBa_K3117020 is a single chain variable fragment (scFv) of the anti-CD3 antibody. This fragment was used to generate a fusion protein to create a bispecific antibody on the one hand directed against CD3, on the other part against GPA33.

Usage and Biology

CD3 is co-expressed with the T cell receptor on T cells. Binding leads to downstream signaling cascades and activation of the T cell (Chetty et al., 1994).

References

1. Chetty, R.; Gatter, K. (1994): CD3: structure, function, and role of immunostaining in clinical practice. In: The Journal of pathology 173 (4), S. 303–307. DOI: 10.1002/path.1711730404.