Difference between revisions of "Part:BBa K3117034"

 
 
Line 3: Line 3:
 
<partinfo>BBa_K3117034 short</partinfo>
 
<partinfo>BBa_K3117034 short</partinfo>
  
−
...
+
The single chain variable fragment of the heavy chain of anti-GPA33 targets the colon cancer surface marker GPA33. Glycoprotein A33 (GPA33) is a well-known surface marker of colon cancer. Under healthy conditions GPA33 is just expressed on gastric cells. On primary and metastatic colorectal cancers, GPA33 is overexpressed in 95% of primary and colorectal cancers [1].
 +
 
  
−
<!-- Add more about the biology of this part here
 
 
===Usage and Biology===
 
===Usage and Biology===
  
−
<!-- -->
+
The single chain fragment targeting GPA33 was used to be fused to the other components of the bispecific antibody to target CD3 and GPA33.
−
<span class='h3bb'>Sequence and Features</span>
+
−
<partinfo>BBa_K3117034 SequenceAndFeatures</partinfo>
+
−
 
+
−
 
+
−
<!-- Uncomment this to enable Functional Parameter display
+
−
===Functional Parameters===
+
−
<partinfo>BBa_K3117034 parameters</partinfo>
+
−
<!-- -->
+

Latest revision as of 01:44, 22 October 2019


scFv VH sequence of anti-GPA33 antibody codon optimized for expression in E.coli

The single chain variable fragment of the heavy chain of anti-GPA33 targets the colon cancer surface marker GPA33. Glycoprotein A33 (GPA33) is a well-known surface marker of colon cancer. Under healthy conditions GPA33 is just expressed on gastric cells. On primary and metastatic colorectal cancers, GPA33 is overexpressed in 95% of primary and colorectal cancers [1].


Usage and Biology

The single chain fragment targeting GPA33 was used to be fused to the other components of the bispecific antibody to target CD3 and GPA33.