Difference between revisions of "Part:BBa K3244014"

 
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<partinfo>BBa_K3244014 parameters</partinfo>
 
<partinfo>BBa_K3244014 parameters</partinfo>
 
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==MIT_MAHE 2020==
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'''Summary'''
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This gene is a member of the interleukin cytokine subfamily. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. This gene has been reviewed for its involvement in cytokine storm inflammatory response.
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==References==
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1. Roy, U. Structure and Function of an Inflammatory Cytokine, Interleukin-2, Analyzed Using the Bioinformatic Approach. Protein J 38, 525–536 (2019). https://doi.org/10.1007/s10930-019-09833-8

Latest revision as of 17:45, 23 October 2020


IL-2 Promoter

IL-2 Promoter for regulation of cytokine expression

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


MIT_MAHE 2020

Summary

This gene is a member of the interleukin cytokine subfamily. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. This gene has been reviewed for its involvement in cytokine storm inflammatory response.

References

1. Roy, U. Structure and Function of an Inflammatory Cytokine, Interleukin-2, Analyzed Using the Bioinformatic Approach. Protein J 38, 525–536 (2019). https://doi.org/10.1007/s10930-019-09833-8