Difference between revisions of "Part:BBa K2619000"
 
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<partinfo>BBa_K2619000 short</partinfo>
 
<partinfo>BBa_K2619000 short</partinfo>
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STEAP3 metalloreductase from Homo sapien is involved in exosome biogenesis. But the detailed mechanism is still unknown
 
  
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STEAP3 metalloreductase, also known as TSAP6 encoding a ferrireductase that is involved in promoting apoptosis and exosome biogenesis. TSAP6 is a glycosylated protein presents in the trans-Golgi network, endosomal–vesicular compartment and cytoplasmic membrane (Lespagnol et al., 2008). One possible mechanism is that TSAP6 regulates its downsteam transferrin receptor genes, which is a process related to exosomal secretion. Although its detailed mechanism of promoting exosome secretion is still unknown, (Lespagnol et al., 2008) have proved that exosome production is severely compromised in TSAP6-null cells.
 
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===Usage and Biology===
 
===Usage and Biology===
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<span class='h3bb'>Sequence and Features</span>
 
<span class='h3bb'>Sequence and Features</span>
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<partinfo>BBa_K2619001 SequenceAndFeatures</partinfo>
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<partinfo>BBa_K2619000 SequenceAndFeatures</partinfo>
  
  

Latest revision as of 09:21, 16 October 2018


STEAP3 metalloreductase/TSAP6/ferrireductase

STEAP3 metalloreductase, also known as TSAP6 encoding a ferrireductase that is involved in promoting apoptosis and exosome biogenesis. TSAP6 is a glycosylated protein presents in the trans-Golgi network, endosomal–vesicular compartment and cytoplasmic membrane (Lespagnol et al., 2008). One possible mechanism is that TSAP6 regulates its downsteam transferrin receptor genes, which is a process related to exosomal secretion. Although its detailed mechanism of promoting exosome secretion is still unknown, (Lespagnol et al., 2008) have proved that exosome production is severely compromised in TSAP6-null cells. Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal BglII site found at 1082
    Illegal BamHI site found at 586
    Illegal BamHI site found at 1388
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal SapI site found at 672