Difference between revisions of "Part:BBa K2543008"

 
 
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<span class='h3bb'>Sequence and Features</span>
 
<span class='h3bb'>Sequence and Features</span>
 
<partinfo>BBa_K2543008 SequenceAndFeatures</partinfo>
 
<partinfo>BBa_K2543008 SequenceAndFeatures</partinfo>
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===References===
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1. [https://www.uniprot.org/uniprot/P08953 UniProtKB - P08953 (TOLL_DROME)] <br />
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2. [https://www.ncbi.nlm.nih.gov/pubmed/2449285 Cell. (1988) The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein.] <br />
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3. [https://www.ncbi.nlm.nih.gov/pubmed/16917510 Nat Rev Immunol. (2006) Toll-like receptors as molecular switches.] <br />
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4. [https://www.ncbi.nlm.nih.gov/pubmed/21209287 J Immunol. (2011) The Drosophila Toll signaling pathway.]
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Latest revision as of 18:05, 8 October 2018


Drosophila Toll transmembrane and intracellular domains / pSB1C3

Toll is a transmembrane protein involved in insect immune defense system to recognize pathogens like bacteria, viruses and fungi. Toll activated by pathogens transmits the signaling to express anti-microbial peptide (AMP) to kill the pathogens. Drosophila transmembrane domain (808-828 aa) and intracellular domain (829-1097 aa) of Toll (dToll) play an important roll in regulating the immune signaling.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    INCOMPATIBLE WITH RFC[21]
    Illegal XhoI site found at 397
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    INCOMPATIBLE WITH RFC[25]
    Illegal NgoMIV site found at 4
  • 1000
    INCOMPATIBLE WITH RFC[1000]
    Illegal BsaI site found at 793

References

1. UniProtKB - P08953 (TOLL_DROME)
2. Cell. (1988) The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein.
3. Nat Rev Immunol. (2006) Toll-like receptors as molecular switches.
4. J Immunol. (2011) The Drosophila Toll signaling pathway.